Forschungszentrum für Haut- und Haarforschung (TP C04)
Klinik für Dermatologie, Venerologie und Allergologie
Charité Universitätsmedizin Berlin

Wissenschaftliche Mitarbeiterin (Post-Doc), Laborleitung

TP C04:
Ex vivo human skin: Impact of skin barrier function and the presence of hair follicles on nanocarrier-based anti-inflammatory therapy

Kontakt:
Tel.  +49 (0)30 450 518 347
Fax  +49 (0)30 450 518 952
Email: fiorenza.rancan (at) charite.de

SFB 1112-Publikationen:

Döge N, Avetisyan A, Hadam S, Pfannes EKB, Rancan F, Blume-Peytavi U, Vogt A 2017. Assessment of skin barrier function and biochemical changes of ex vivo human skin in response to physical and chemical barrier disruption. Accepted for publication in Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.12.012

Klossek A, Thierbach S, Rancan F, Vogt A, Blume-Peytavi U, Rühl E 2017. Studies for improved understanding of lipid distributions in human skin by combining stimulated and spontaneous Raman microscopy. Eur J Pharm Biopharm, in press, DOI: 10.1016/j.ejpb.2016.11.001

Rancan F, Giulbudagian M, Jurisch J, Blume-Peytavi U, Calderón M, Vogt A 2017. Drug delivery across intact and disrupted skin barrier: identification of cell populations interacting with penetrated thermoresponsive nanogels. Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.11.017 

Yamamoto K, Klossek A, Flesch R, Rancan F, Weigand M, Bykova I,Bechtel M, Ahlberg S, Vogt A, Blume-Peytavi U, Schrade P, Bachmann S, Hedtrich S, Schäfer-Korting M, Rühl E 2017. Influence of the skin barrier on the penetration of topically-applied dexamethasone probed by soft X-ray spectromicroscopy. Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.12.005

Schulz R, Yamamoto K, Klossek A, Flesch R, Hönzke S, Rancan F, Vogt A, Blume-Peytavi U, Hedtrich S, Schäfer-Korting M, Rühl E, Netz RR 2017. Data-based modeling of drug penetration profiles explains human skin barrier function by the interplay of diffusivity and free energy profiles. Proc Nat Acad Sci DOI 10.1073/pnas.1620636114 (epublication ahead of print)

Döge N, Hönzke S, Schumacher F, Balzus B, Colombo M, Hadam S, Rancan F, Blume-Peytavi U, Schäfer-Korting M, Schindler A, Rühl E, Stahl Skov P, Church M, Hedtrich S, Kleuser B, Bodmeier R, Vogt A 2017. Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivohuman skin -assessment by intradermal microdialysis and extraction from the different skin layers. J Control Release 242:25-34 DOI 10.1016/j.jconrel.2016.07.009

Giulbudagian M, Rancan F, Klossek A, Yamamoto K, Jurisch J, Colombo Neto V, Schrade P, Bachmann S, Rühl E, Blume-Peytavi U, Vogt A, Calderón M 2016. Correlation between the chemical composition of thermoresponsive nanogels and their interaction with the skin barrier. J Contr Release 243:323-332 DOI 10.1016/j.jconrel.2016.10.022

Rancan F, Asadian-Birjand M , Dogan S, Graf C, Cuellar L, Lommatzsch S, Blume-Peytavi U, Calderón M, Vogt A 2017. Effects of thermoresponsivity and softness of polyglycerol-based nanogels on skin penetration and cellular uptake. J Control Release 228:159-169 DOI 10.1016/j.jconrel.2016.02.047

Yamamoto K, Klossek A, Flesch R, Ohigashi T, Fleige E, Rancan F, Ahlberg S, Vogt A, Blume-Peytavi U, Schrade P, Bachmann S, Haag R, Hedtrich S, Schäfer-Korting M, Kosugi N, Rühl E 2016. Core-multishell nanocarriers: Transport and release of dexamethasone probed by soft X-ray spectromicroscopy. J Control Release 242:64-70 DOI 10.1016/j.jconrel.2016.08.028

Ahlberg S, Rancan F, Epple M, Loza K, Höppe D, Lademann J, Vogt A, Kleuser B, Gerecke C, Meinke MC 2016. Comparison of different methods to study effects of silver nanoparticles on the pro- and antioxicant status of human keratinocytes and fibroblasts. Methods 109:55-63 DOI 10.1016/j.ymeth.2016.05.015

Asadian-Birjand M, Bergueiro J, Rancan F, Cuggino JC, Mutihac RC, Achazi K, Derneddle J, Blume-Peytavi U, Vogt A, Calderón M 2015. Engineering thermoresponsive polyether-based nanogels for temperature dependent skin penetration. Polym Chem 6:5827-5831 DOI 10.1039/c5py00924c

Graf C, Nordmeyer D, Ahlberg S, Raabe J, Vogt A, Lademann J, Rancan F, Rühl E 2015. Penetration of spherical and rod-like gold nanoparticles into intact and barrier- disrupted human skin. Proc SPIE 9338, 93381L-1. DOI 10.1117/12.2079719 (epub, 8 pages)

Volz P, Boreham A, Wolf A, Kim T-Y, Balke J, Frombach J, Hadam S, Afraz Z, Rancan F, Blume-Peytavi U, Vogt A, Alexiev U 2015. Application of single molecule fluorescence microscopy to characterize the penetration of a large amphiphilic molecule in the stratum corneum of human skin. Int J Mol Sci 16: 6960-6977 DOI 10.3390/ijms16046960

Yamamoto K, Flesch R, Ohigashi T, Hedtrich S, Klossek A, Patoka P, Ulrich G, Ahlberg S, Rancan F, Vogt A, Blume-Peytavi U, Schrade P, Bachmann S, Schäfer-Korting M, Kosugi N, Rühl E 2015. Selective probing of the penetration of dexamethasone into human skin by soft-X-Ray spectromicroscopy. Anal Chem 87:6173-6179 DOI 10.1021/acs.analchem.5b00800

Rancan F, Blume-Peytavi U, Vogt A 2014. Utilization of biodegradable polymeric materials as delivery agents in dermatology. Clin Cosmet Investig Dermatol 7:23-34 DOI 10.2147/CCID.S39559 (Review)